Kodi biomarker yatsopano yamagazi ingathandize kulosera za chiopsezo cha Alzheimer's?

Kafukufuku watsopano akuwonetsa kuti ma astrocyte, mtundu wa cell ya muubongo, ndi wofunikira pakulumikiza amyloid-β ndi magawo oyambilira a tau pathology.Karyna Bartashevich/Stocksy

• Ma reactive astrocyte, mtundu wa cell ya muubongo, atha kuthandiza asayansi kumvetsetsa chifukwa chake anthu ena okhala ndi chidziwitso chathanzi komanso ma amyloid-β deposits muubongo wawo sakhala ndi zizindikiro zina za Alzheimer's, monga ma protein osakanikirana a tau.
• Kafukufuku wopitilira 1,000 omwe adatenga nawo gawo adayang'ana ma biomarkers ndipo adapeza kuti amyloid-β idangolumikizidwa ndi kuchuluka kwa tau mwa anthu omwe anali ndi zizindikiro za astrocyte reactivity.
• Zomwe zapezazi zikusonyeza kuti ma astrocyte ndi ofunikira polumikiza amyloid-β ndi magawo oyambirira a tau pathology, zomwe zingasinthe momwe timafotokozera matenda oyambirira a Alzheimer's.

Kuchulukana kwa zolembera za amyloid ndi mapuloteni osakanikirana a tau muubongo kwakhala kuganiziridwa kuti ndizomwe zimayambitsaMatenda a Alzheimer's (AD).

Kukula kwa mankhwala osokoneza bongo kumangoyang'ana kwambiri ku amyloid ndi tau, kunyalanyaza zomwe zimachitika muubongo wina, monga neuroimmune system.

Tsopano, kafukufuku watsopano wochokera ku yunivesite ya Pittsburgh School of Medicine akusonyeza kuti ma astrocyte, omwe ndi maselo a ubongo ooneka ngati nyenyezi, amagwira ntchito yofunikira kuti athe kudziwa momwe Alzheimer's ikupita.

Gwero Lodalirika la Astrocyteszambiri mu minofu ya ubongo.Pamodzi ndi ma cell ena a glial, maselo oteteza thupi ku ubongo, ma astrocyte amathandizira ma neuron powapatsa michere, mpweya, ndi chitetezo ku tizilombo toyambitsa matenda.

M'mbuyomu gawo la ma astrocyte mukulankhulana kwa neuronal silinalandiridwe popeza ma cell a glial samayendetsa magetsi ngati ma neuroni.Koma kafukufuku wa University of Pittsburg amatsutsa lingaliro ili ndikuwunikira mbali yofunika kwambiri ya astrocyte mu thanzi laubongo ndi matenda.

Zotsatirazo zidasindikizidwa posachedwa muNature MedicineTrusted Source.

Kafukufuku wam'mbuyomu akuwonetsa kuti kusokonezeka kwa njira zaubongo kupitilira kulemedwa kwa amyloid, monga kuchuluka kwa kutupa muubongo, kumatha kukhala ndi gawo lofunikira pakuyambitsa kutsatana kwa ma neuronal kufa komwe kumabweretsa kuchepa kwachidziwitso kwa Alzheimer's.

Mu kafukufuku watsopanoyu, ofufuza adayesa magazi kwa anthu 1,000 ochokera ku maphunziro atatu osiyana okhudza achikulire omwe ali ndi thanzi labwino komanso opanda amyloid buildup.

Adasanthula zitsanzo zamagazi kuti awone ma biomarker a astrocyte reactivity, makamaka glial fibrillary acidic protein (GFAP), kuphatikiza kukhalapo kwa pathological tau.

Ofufuzawo adapeza kuti okhawo omwe anali ndi zolemetsa za amyloid komanso zolembera zamagazi zomwe zikuwonetsa kuyambika kwa zakuthambo kapena kuchitapo kanthu komwe atha kukhala ndi zizindikiro za Alzheimer's m'tsogolomu.